Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.41 |
| ▸ | ITGAV | P06756 | 1/20 | 0.41 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.41 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL305860 | 0.91 | ALDH1A1 (0.55) | ALDH1A1POLBEIF2AK2RAB9AMAPT | |
| SCHEMBL1259982 | 0.82 | ALDH1A1 (0.46) | ALDH1A1POLBRAB9ANPC1MAPT | |
| SCHEMBL10022670 | 0.81 | ALDH1A1 (0.57) | ALDH1A1POLBEIF2AK2MAPTMEN1 | |
| SCHEMBL2199529 | 0.78 | KMT2A (0.41) | ALDH1A1POLBEIF2AK2MAPTMEN1 | |
| SCHEMBL146714 | 0.77 | NPC1 (0.56) | ALDH1A1POLBEIF2AK2RAB9ANPC1 | |
| SCHEMBL5727688 | 0.77 | POLB (0.47) | ALDH1A1POLBEIF2AK2RAB9ANPC1 | |
| SCHEMBL19002557 | 0.76 | L3MBTL1 (0.53) | ALDH1A1EIF2AK2RAB9ANPC1MAPT | |
| SCHEMBL457815 | 0.76 | EIF2AK2 (0.46) | ALDH1A1POLBEIF2AK2RAB9ANPC1 | |
| SCHEMBL4667907 | 0.76 | EIF2AK2 (0.39) | ALDH1A1POLBEIF2AK2RAB9ANPC1 | |
| SCHEMBL4712786 | 0.76 | DDB1 (0.56) | ALDH1A1POLBEIF2AK2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673375-A1 | FUSED BENZO COMPOUNDS | H. LUNDBECK A/S (DK) | 1995-09-27 | — | — | EP | disclosed |
| WO-1994013659-A1 | FUSED BENZO COMPOUNDS | H. LUNDBECK A/S (DK) | 1994-06-23 | — | — | WO | disclosed |