Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KHK | P50053 | 1/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9207837 | 0.85 | PTGS2 (0.51) | PTGS2PTGS1MAPTCA9CA1 | |
| SCHEMBL9204734 | 0.84 | PTGS1 (0.53) | PTGS2PTGS1MAPTCA9POLB | |
| SCHEMBL9201889 | 0.84 | PTGS2 (0.57) | PTGS2PTGS1CA9 | |
| SCHEMBL8639378 | 0.82 | PTGS2 (0.53) | PTGS2PTGS1MAPTCA9POLB | |
| SCHEMBL8645136 | 0.82 | PTGS1 (0.51) | PTGS2PTGS1MAPTCA9POLB | |
| SCHEMBL9209095 | 0.82 | PTGS2 (0.63) | PTGS2PTGS1NR3C2 | |
| SCHEMBL9201792 | 0.82 | PTGS2 (0.63) | PTGS2PTGS1NR3C2 | |
| SCHEMBL6343738 | 0.82 | PTGS2 (0.73) | PTGS2PTGS1CA9CA1CA2 | |
| SCHEMBL6351268 | 0.82 | PTGS2 (0.73) | PTGS2PTGS1CA9CA1CA2 | |
| SCHEMBL8642066 | 0.81 | PTGS2 (0.47) | PTGS2PTGS1MAPTALDH1A1NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |