Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 2/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | RPA1 | P27694 | 1/20 | 0.43 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8638380 | 0.90 | RPA1 (0.55) | CA9PTGS2PTGS1KDM4ETDP1 | |
| SCHEMBL5698731 | 0.85 | PTGS1 (0.65) | CA9PTGS2PTGS1CHRNA7KDM4E | |
| SCHEMBL9201580 | 0.84 | CA9 (0.59) | CA9PTGS2PTGS1CHRNA7RPA1 | |
| SCHEMBL9210890 | 0.84 | CA9 (0.74) | CA9PTGS2PTGS1CHRNA7SMN1; SMN2 | |
| SCHEMBL9209766 | 0.84 | MEN1 (0.56) | PTGS2PTGS1CHRNA7SMN1; SMN2RPA1 | |
| SCHEMBL9199551 | 0.84 | MEN1 (0.56) | PTGS2PTGS1CHRNA7SMN1; SMN2RPA1 | |
| SCHEMBL8639378 | 0.84 | PTGS2 (0.53) | CA9PTGS2PTGS1SMN1; SMN2NFKB1 | |
| SCHEMBL9204734 | 0.83 | PTGS1 (0.53) | CA9PTGS2PTGS1KDM4ESMN1; SMN2 | |
| SCHEMBL6352446 | 0.83 | PTGS2 (0.67) | CA9PTGS2PTGS1CHRNA7SMN1; SMN2 | |
| SCHEMBL6353551 | 0.83 | CA9 (0.82) | CA9PTGS2PTGS1CHRNA7SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |