Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | RXRG | P48443 | 1/20 | 0.44 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.42 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9209960 | 0.85 | AOC3 (0.64) | PTGS2PTGS1AOC3CHRNA7 | |
| SCHEMBL9208745 | 0.83 | MALT1 (0.67) | AOC3RXRARXRBRXRGMALT1 | |
| SCHEMBL9203794 | 0.81 | PTGS2 (0.48) | PTGS2PTGS1CHRNA7RXRARXRB | |
| SCHEMBL9208424 | 0.80 | PTGS2 (0.49) | PTGS2PTGS1CHRNA7RXRARXRB | |
| SCHEMBL9205227 | 0.80 | PTGS2 (0.51) | PTGS2PTGS1CHRNA7RXRARXRB | |
| SCHEMBL9211086 | 0.78 | PTGS2 (0.45) | PTGS2PTGS1CHRNA7RXRARXRB | |
| SCHEMBL9202688 | 0.78 | CHRNA7 (0.71) | PTGS2CHRNA7MEN1KMT2AATM | |
| SCHEMBL9200872 | 0.78 | CHRNA7 (0.71) | PTGS2CHRNA7MEN1KMT2AATM | |
| SCHEMBL9204658 | 0.77 | KMT2A (0.72) | PTGS2CHRNA7MEN1KMT2AATM | |
| SCHEMBL9204760 | 0.77 | KMT2A (0.72) | PTGS2CHRNA7MEN1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |