Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9203794 | 0.88 | PTGS2 (0.48) | PTGS2PTGS1KCNH2CHRNA7RXRA | |
| SCHEMBL9205227 | 0.87 | PTGS2 (0.51) | PTGS2PTGS1KCNH2CHRNA7RXRA | |
| SCHEMBL17378009 | 0.85 | PTGS2 (0.54) | PTGS2PTGS1KCNH2CHRNA7RXRA | |
| SCHEMBL9211086 | 0.85 | PTGS2 (0.45) | PTGS2PTGS1KCNH2CHRNA7RXRA | |
| SCHEMBL9202494 | 0.83 | PTGS2 (0.52) | PTGS2PTGS1CHRNA7MEN1KMT2A | |
| SCHEMBL9207835 | 0.82 | PTGS2 (0.51) | PTGS2PTGS1CHRNA7MEN1KMT2A | |
| SCHEMBL27742806 | 0.82 | MEN1 (0.58) | PTGS2PTGS1KCNH2RXRARXRB | |
| SCHEMBL9208745 | 0.80 | MALT1 (0.67) | RXRARXRBRXRG | |
| SCHEMBL9201624 | 0.80 | PTGS2 (0.47) | PTGS2PTGS1KCNH2CHRNA7RXRA | |
| SCHEMBL9206412 | 0.80 | PTGS2 (0.49) | PTGS2PTGS1CHRNA7MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |