Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9201843 | 0.84 | HSD11B1 (0.54) | HSD11B1ALDH1A1L3MBTL1LMNANPSR1 | |
| SCHEMBL9199978 | 0.83 | HSD11B1 (0.43) | HSD11B1ALDH1A1L3MBTL1LMNANPSR1 | |
| SCHEMBL96764 | 0.78 | HSD11B1 (0.56) | HSD11B1ALDH1A1L3MBTL1LMNANPSR1 | |
| SCHEMBL5536934 | 0.77 | HSD11B1 (0.49) | HSD11B1ALDH1A1L3MBTL1LMNANPSR1 | |
| SCHEMBL5546087 | 0.77 | HSD11B1 (0.50) | HSD11B1ALDH1A1L3MBTL1LMNANPSR1 | |
| SCHEMBL5546084 | 0.77 | HSD11B1 (0.50) | HSD11B1ALDH1A1L3MBTL1LMNANPSR1 | |
| SCHEMBL8408605 | 0.76 | AR (0.46) | HSD11B1ALDH1A1MAPTPTGS2TSHR | |
| SCHEMBL2968355 | 0.73 | HSD11B1 (0.61) | HSD11B1ALDH1A1L3MBTL1LMNANPSR1 | |
| SCHEMBL14605979 | 0.71 | HSD11B1 (1.00) | HSD11B1ALDH1A1L3MBTL1LMNAMAPT | |
| SCHEMBL14438051 | 0.69 | ALDH1A1 (0.52) | ALDH1A1L3MBTL1LMNANPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0489877-B1 | ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 2-AMINO-6-PHENYL-4H-PYRAN-4-ONES | UPJOHN CO (US) | 1995-09-20 | — | — | EP | disclosed |
| EP-0525123-A1 | ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES. | UPJOHN CO (US) | 1993-02-03 | — | — | EP | disclosed |