Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | STAT1 | P42224 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17076613 | 0.66 | ALDH1A1 (0.33) | ALDH1A1POLBHPGDKMT2AMEN1 | |
| SCHEMBL18153203 | 0.64 | HTR2A (0.44) | ALDH1A1POLBHPGDKMT2AMEN1 | |
| SCHEMBL5508076 | 0.63 | ALDH1A1 (0.52) | ALDH1A1POLBHPGDKMT2AMEN1 | |
| SCHEMBL9218509 | 0.63 | ALDH1A1 (0.52) | ALDH1A1POLBHPGDKMT2AMEN1 | |
| SCHEMBL5507494 | 0.63 | ALDH1A1 (0.52) | ALDH1A1POLBHPGDKMT2AMEN1 | |
| SCHEMBL14128135 | 0.62 | SMN1; SMN2 (0.36) | ALDH1A1POLBKMT2AMEN1GAA | |
| SCHEMBL14205089 | 0.58 | GAA (0.58) | ALDH1A1POLBHPGDKMT2AMEN1 | |
| SCHEMBL8505604 | 0.58 | GAA (0.58) | ALDH1A1POLBHPGDKMT2AMEN1 | |
| SCHEMBL9912528 | 0.58 | ALDH1A1 (0.54) | ALDH1A1HPGDKMT2AMEN1GAA | |
| SCHEMBL13704120 | 0.58 | GPR3 (0.60) | ALDH1A1POLBHPGDKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0682523-A1 | USE OF TRICYCLIC ISOINDOLINONES AS ANTIVIRAL DRUGS, AND NEW, OPTICALLY ACTIVE ISOINDOLINONES | Roche Diagnostics GmbH (DE) | 1995-11-22 | — | — | EP | disclosed |
| WO-1992015310-A1 | USE OF TRICYCLIC ISOINDOLINONES AS ANTIVIRAL DRUGS, AND NEW, OPTICALLY ACTIVE ISOINDOLINONES | BOEHRINGER MANNHEIM GMBH (DE) | 1992-09-17 | — | — | WO | disclosed |