Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7542871 | 0.76 | KDM4E (0.35) | ALDH1A1RAB9AMAPTKDM4EHPGD | |
| SCHEMBL11228949 | 0.76 | GFER (0.42) | ALDH1A1MAPTGAAKDM4EHPGD | |
| SCHEMBL11769838 | 0.67 | ALDH1A1 (0.47) | HTR2AHTR2CHTR2BALDH1A1RAB9A | |
| SCHEMBL2311024 | 0.66 | GABRP (0.34) | — | |
| SCHEMBL31314714 | 0.66 | HTR2B (0.45) | HTR2AHTR2CHTR2BALDH1A1GAA | |
| SCHEMBL11377237 | 0.65 | HTR2A (0.57) | HTR2AHTR2CHTR2BALDH1A1RAB9A | |
| SCHEMBL18153233 | 0.64 | HTR2A (0.59) | HTR2AHTR2CHTR2BALDH1A1RAB9A | |
| SCHEMBL29987788 | 0.64 | HTR2A (0.59) | HTR2AHTR2CHTR2BALDH1A1RAB9A | |
| SCHEMBL9202042 | 0.64 | ALDH1A1 (0.41) | HTR2AHTR2CHTR2BALDH1A1RAB9A | |
| SCHEMBL11843282 | 0.64 | HTR2A (0.37) | HTR2AHTR2CHTR2BALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3286195-A1 | INDAZOLONES AS MODULATORS OF TNF SIGNALING | AbbVie Inc. (US) | 2018-02-28 | — | — | EP | claimed |
| WO-2016168638-A1 | INDAZOLONES AS MODULATORS OF TNF SIGNALING | ABBVIE INC. (US) | 2016-10-20 | — | — | WO | claimed |
| EP-3286195-A1 | INDAZOLONES AS MODULATORS OF TNF SIGNALING | AbbVie Inc. (US) | 2018-02-28 | — | — | EP | disclosed |
| WO-2016168638-A1 | INDAZOLONES AS MODULATORS OF TNF SIGNALING | ABBVIE INC. (US) | 2016-10-20 | — | — | WO | disclosed |