SCHEMBL920254

SCHEMBL920254

Nc1ncccc1C(=O)NCc1cccc(Oc2ccc(OC(F)(F)F)cc2)c1

nearest known ligand 0.60

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 2/20 0.60
PPARG P37231 2/20 0.52
PPARD Q03181 2/20 0.52
PPARA Q07869 2/20 0.52
ROCK2 O75116 2/20 0.52
ROCK1 Q13464 2/20 0.52
MAPK8 P45983 1/20 0.50
HPGD P15428 2/20 0.49
KMT2A Q03164 1/20 0.49
HTR2C P28335 1/20 0.49
KDM4E B2RXH2 1/20 0.47
USP2 O75604 1/20 0.47
ALDH1A1 P00352 1/20 0.47
KCNB1 Q14721 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL920582 0.95 MAPK14 (0.58) MAPK14PPARGPPARDPPARAROCK2
SCHEMBL921833 0.92 MAPK14 (0.54) MAPK14PPARGPPARDPPARAROCK2
SCHEMBL921976 0.91 MAPK8 (0.52) MAPK14MAPK8HPGDKMT2AHTR2C
SCHEMBL920802 0.91 MAPK14 (0.51) MAPK14PPARGPPARDPPARAROCK2
SCHEMBL919838 0.90 HPGD (0.52) MAPK14PPARGPPARDPPARAMAPK8
SCHEMBL921323 0.90 MAPK14 (0.57) MAPK14PPARGPPARDPPARAMAPK8
SCHEMBL921886 0.90 MAPK14 (0.50) MAPK14PPARGPPARDPPARAROCK2
SCHEMBL920185 0.90 PPARG (0.51) MAPK14PPARGPPARDPPARAROCK2
SCHEMBL920580 0.89 MAPK14 (0.51) MAPK14PPARGPPARDPPARAROCK2
SCHEMBL919696 0.89 MAPK14 (0.52) MAPK14PPARGPPARDPPARAROCK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
EP-2248423-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS Sumitomo Chemical Company, Limited (JP) 2010-11-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS WIZ, TST, NAT1 MAPK14 905/4885PPARG 391/4885PPARD 360/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.