SCHEMBL921833

SCHEMBL921833

Nc1ncccc1C(=O)NCc1ccc(Oc2cccc(OC(F)(F)F)c2)cc1

nearest known ligand 0.54

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 2/20 0.54
MAPK8 P45983 1/20 0.50
HTR2C P28335 1/20 0.49
PPARG P37231 1/20 0.48
PPARD Q03181 1/20 0.48
PPARA Q07869 1/20 0.48
ROCK2 O75116 1/20 0.47
ROCK1 Q13464 1/20 0.47
KLKB1 P03952 1/20 0.45
NAMPT P43490 1/20 0.45
EGLN1 Q9GZT9 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL920582 0.93 MAPK14 (0.58) MAPK14MAPK8HTR2CPPARGPPARD
SCHEMBL921976 0.93 MAPK8 (0.52) MAPK14MAPK8HTR2CKLKB1EGLN1
SCHEMBL920254 0.92 MAPK14 (0.60) MAPK14MAPK8HTR2CPPARGPPARD
SCHEMBL920966 0.90 MAPK8 (0.46) MAPK14MAPK8HTR2CKLKB1EGLN1
SCHEMBL919622 0.88 MAPK14 (0.54) MAPK14MAPK8
SCHEMBL920035 0.87 MAPK8 (0.45) MAPK14MAPK8HTR2CPPARDPPARA
SCHEMBL919923 0.87 MAPK8 (0.45) MAPK14MAPK8HTR2CKLKB1EGLN1
SCHEMBL921412 0.87 MAPK8 (0.45) MAPK14MAPK8HTR2CKLKB1EGLN1
SCHEMBL921664 0.87 P2RX7 (0.47) MAPK14MAPK8HTR2CPPARGPPARD
SCHEMBL921271 0.87 HPGD (0.57) MAPK8EGLN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
EP-2248423-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS Sumitomo Chemical Company, Limited (JP) 2010-11-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS WIZ, TST, NAT1 MAPK14 905/4885MAPK8 2313/4885HTR2C 4348/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.