Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.51 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.50 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.47 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 3/20 | 0.47 |
| ▸ | PPARD | Q03181 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9203661 | 1.00 | NPC1 (0.53) | NPC1RAB9APTGS2CYSLTR2CYSLTR1 | |
| SCHEMBL9206284 | 0.93 | LTB4R (0.53) | NPC1RAB9APTGS2CYSLTR2CYSLTR1 | |
| SCHEMBL9206279 | 0.93 | LTB4R (0.53) | NPC1RAB9APTGS2CYSLTR2CYSLTR1 | |
| SCHEMBL9201444 | 0.85 | LTB4R (0.54) | NPC1RAB9AKMT2ALTB4RLTB4R2 | |
| SCHEMBL9201451 | 0.85 | LTB4R (0.54) | NPC1RAB9AKMT2ALTB4RLTB4R2 | |
| SCHEMBL9199980 | 0.85 | LTB4R (0.66) | NPC1RAB9ACYSLTR2CYSLTR1KMT2A | |
| SCHEMBL9206318 | 0.84 | LTB4R (0.59) | NPC1RAB9AKMT2ALTB4RLTB4R2 | |
| SCHEMBL9206314 | 0.84 | LTB4R (0.59) | NPC1RAB9AKMT2ALTB4RLTB4R2 | |
| SCHEMBL9201817 | 0.82 | LTB4R (0.77) | LTB4RLTB4R2 | |
| SCHEMBL9857423 | 0.81 | IDO1 (0.47) | NPC1RAB9APTGS2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538416-B1 | SUBSTITUTED MONOCYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4 ANTAGONIST ACTIVITY | RHONE POULENC RORER INT (US) | 1995-08-09 | — | — | EP | disclosed |
| US-5232948-A | SUBSTITUTED MONOCYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1993-08-03 | — | — | US | disclosed |