Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 4/20 | 0.60 |
| ▸ | HTR2A | P28223 | 4/20 | 0.60 |
| ▸ | HTR2C | P28335 | 4/20 | 0.60 |
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30888858 | 0.91 | HTR2B (0.71) | HTR2BHTR2AHTR2CHTR1AMTNR1A | |
| SCHEMBL9211145 | 0.89 | HTR2B (0.50) | HTR2BHTR2AHTR2CHTR1AMTNR1A | |
| SCHEMBL9202189 | 0.83 | HTR2B (0.54) | HTR2BHTR2AHTR2CHTR1AMTNR1A | |
| SCHEMBL9210783 | 0.80 | LMNA (0.48) | HTR2BHTR2AHTR2CHTR1AMTNR1A | |
| SCHEMBL9203861 | 0.80 | HTR2B (0.50) | HTR2BHTR2AHTR2CHTR1AMTNR1A | |
| SCHEMBL12180277 | 0.79 | HTR2B (0.70) | HTR2BHTR2AHTR2CHTR1AMTNR1A | |
| SCHEMBL9206198 | 0.78 | THRA (0.44) | HTR2BHTR2AHTR2CHTR1ATRPM8 | |
| SCHEMBL24766434 | 0.75 | HTR2B (1.00) | HTR2BHTR2AHTR2CHTR1AMTNR1A | |
| SCHEMBL17817943 | 0.75 | HTR2B (0.74) | HTR2BHTR2AHTR2CHTR1AMTNR1A | |
| SCHEMBL9673757 | 0.75 | HTR2B (1.00) | HTR2BHTR2AHTR2CHTR1AMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674619-A1 | TRYPTAMINE ANALOGUES AS 5-HT 1?-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | claimed |
| WO-1994014770-A1 | TRYPTAMINE ANALOGUES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-07 | — | — | WO | claimed |
| EP-0674619-A1 | TRYPTAMINE ANALOGUES AS 5-HT 1?-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994014770-A1 | TRYPTAMINE ANALOGUES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-07 | — | — | WO | disclosed |