Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 5/20 | 0.43 |
| ▸ | DRD2 | P14416 | 5/20 | 0.43 |
| ▸ | HTR7 | P34969 | 4/20 | 0.43 |
| ▸ | HTR6 | P50406 | 4/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9205349 | 0.84 | ABCC1 (0.57) | LMNAHTR1AHTR2ADRD2HTR7 | |
| SCHEMBL9210187 | 0.81 | HTR1A (0.64) | HTR1AHTR2ADRD2HTR7HTR6 | |
| Hydrochloric Acid SCHEMBL8787792 | 0.81 | DRD2 (0.44) | HTR1AMAPTDRD2DRD3DRD4 | |
| SCHEMBL9210900 | 0.80 | HTR1A (0.65) | HTR1AHTR2ADRD2HTR7HTR6 | |
| Hydrochloric Acid SCHEMBL9213478 | 0.79 | HTR1A (0.64) | HTR1AHTR2ADRD2HTR7HTR6 | |
| Hydrochloric Acid SCHEMBL9206187 | 0.79 | HTR1A (0.62) | HTR1AHTR2ADRD2HTR7HTR6 | |
| SCHEMBL9567458 | 0.78 | HTR1A (0.49) | LMNAMEN1KMT2AHTR1AHTR2A | |
| SCHEMBL10513427 | 0.77 | HTR1A (0.40) | LMNAMEN1KMT2AHTR1AKDM4E | |
| SCHEMBL6361478 | 0.77 | HTR1A (0.49) | HTR1AHTR7HTR6 | |
| Hydrochloric Acid SCHEMBL9262251 | 0.77 | HTR1A (0.48) | LMNAMEN1KMT2AHTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0345808-B1 | 1-Indolylalkyl-4-(substituted-pyridinyl)piperazines | BRISTOL MYERS SQUIBB CO (US) | 1995-01-11 | — | — | EP | claimed |
| US-4954502-A | Antidepressants | BRISTOL-MYERS SQUIBB COMPANY (US) | 1990-09-04 | — | — | US | claimed |
| EP-0345808-A1 | 1-Indolylalkyl-4-(substituted-pyridinyl)piperazines | Bristol-Myers Squibb Company (US) | 1989-12-13 | — | — | EP | claimed |