Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 7/20 | 0.40 |
| ▸ | BACE2 | Q9Y5Z0 | 5/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.38 |
| ▸ | HTR3A | P46098 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8566875 | 1.00 | BACE1 (0.40) | BACE1BACE2SLC6A2SLC6A4PARP15 | |
| SCHEMBL9210057 | 0.89 | CA12 (0.39) | KDM4ELMNAMAPTRAB9A | |
| SCHEMBL9207736 | 0.88 | SLC6A2 (0.41) | SLC6A2SLC6A4PARP15PARP10HTR3A | |
| SCHEMBL9208921 | 0.85 | HTR1A (0.42) | SLC6A2SLC6A4SLC6A3KDM4EMAPT | |
| SCHEMBL9213510 | 0.84 | MIF (0.31) | BRD4MAOB | |
| SCHEMBL9215789 | 0.84 | ALOX5 (0.44) | KCNH2MAOBMAOAMAPTRAB9A | |
| SCHEMBL9206290 | 0.84 | HRH3 (0.33) | SLC6A2SLC6A4SLC6A3MAOBKDM4E | |
| SCHEMBL9204689 | 0.84 | ALOX5 (0.44) | KCNH2MAOBMAOAMAPTRAB9A | |
| SCHEMBL9208097 | 0.84 | MCHR1 (0.40) | — | |
| SCHEMBL9209400 | 0.84 | ALOX5 (0.44) | KCNH2MAOBMAOAMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0425209-B1 | Naphthyloxazolidone derivatives | TANABE SEIYAKU CO (JP) | 1995-05-10 | — | — | EP | disclosed |
| US-5332754-A | Antidepressant | TANABE SEIYAKU CO., LTD. (JP) | 1994-07-26 | — | — | US | disclosed |
| US-5182296-A | Antidepressants | TANABE SEIYAKY CO., LTD. (JP) | 1993-01-26 | — | — | US | disclosed |