Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9205972 | 0.94 | SIGMAR1 (0.50) | SLC2A1DRD2DRD3 | |
| Oxalic Acid SCHEMBL9277534 | 0.85 | NMT2 (0.50) | DRD3ALDH1A1 | |
| Oxalic Acid SCHEMBL9203704 | 0.84 | SIGMAR1 (0.62) | — | |
| Oxalic Acid SCHEMBL9202249 | 0.80 | BCHE (0.60) | — | |
| Oxalic Acid SCHEMBL9205537 | 0.79 | SIGMAR1 (0.66) | — | |
| SCHEMBL9206183 | 0.76 | BCHE (0.61) | — | |
| SCHEMBL10459171 | 0.76 | SLC2A1 (0.71) | SLC2A1AKR1B1ALDH1A1MAPTHPGD | |
| SCHEMBL8115506 | 0.75 | SLC2A1 (0.73) | SLC2A1AKR1B1ALDH1A1MAPTHPGD | |
| Oxalic Acid SCHEMBL9207527 | 0.75 | SLC2A1 (0.49) | SLC2A1AKR1B1ALDH1A1 | |
| SCHEMBL9204614 | 0.75 | SIGMAR1 (0.68) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0430693-B1 | Pyrimidinedione derivative compounds, method for preparing same, and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS (JP) | 1995-05-31 | — | — | EP | disclosed |
| US-5114941-A | PYRIMIDINEDIONE DERIVATIVE COMPOUNDS, METHOD FOR PREPARING SAME, AND ANTIARRYTHMIC AGENTS CONTAINING SAME | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1992-05-19 | — | — | US | disclosed |
| EP-0430693-A2 | Pyrimidinedione derivative compounds, method for preparing same, and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1991-06-05 | — | — | EP | disclosed |