Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9205207 | 0.94 | SLC2A1 (0.51) | SLC2A1DRD2DRD3 | |
| Oxalic Acid SCHEMBL9277534 | 0.85 | NMT2 (0.50) | SIGMAR1DRD3 | |
| Oxalic Acid SCHEMBL9205537 | 0.84 | SIGMAR1 (0.66) | SIGMAR1 | |
| SCHEMBL9204614 | 0.80 | SIGMAR1 (0.68) | SIGMAR1 | |
| Oxalic Acid SCHEMBL9205890 | 0.79 | SIGMAR1 (0.60) | SIGMAR1 | |
| Oxalic Acid SCHEMBL9203704 | 0.78 | SIGMAR1 (0.62) | SIGMAR1 | |
| SCHEMBL9201664 | 0.75 | SIGMAR1 (0.64) | SIGMAR1 | |
| Oxalic Acid SCHEMBL9429328 | 0.74 | KDM4E (0.52) | — | |
| SCHEMBL21174962 | 0.74 | MAOB (0.70) | MAOBSLC2A1 | |
| Oxalic Acid SCHEMBL9202249 | 0.73 | BCHE (0.60) | SIGMAR1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0430693-B1 | Pyrimidinedione derivative compounds, method for preparing same, and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS (JP) | 1995-05-31 | — | — | EP | disclosed |
| US-5114941-A | PYRIMIDINEDIONE DERIVATIVE COMPOUNDS, METHOD FOR PREPARING SAME, AND ANTIARRYTHMIC AGENTS CONTAINING SAME | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1992-05-19 | — | — | US | disclosed |
| EP-0430693-A2 | Pyrimidinedione derivative compounds, method for preparing same, and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1991-06-05 | — | — | EP | disclosed |