Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.52 |
| ▸ | CA9 | Q16790 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.37 |
| ▸ | MARS1 | P56192 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9208211 | 0.88 | CA9 (0.52) | CHRNA7CA9MITFALDH1A1SMN1; SMN2 | |
| SCHEMBL9205210 | 0.87 | CHRNA7 (0.54) | CHRNA7CA9MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9200442 | 0.86 | PTGS2 (0.45) | CHRNA7CA9MAPTALDH1A1PTGS2 | |
| SCHEMBL9206790 | 0.85 | CHRNA7 (0.54) | CHRNA7CA9MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9200872 | 0.81 | CHRNA7 (0.71) | CHRNA7CA9PTGS2FAAHTHRB | |
| SCHEMBL9202688 | 0.81 | CHRNA7 (0.71) | CHRNA7CA9PTGS2FAAHTHRB | |
| SCHEMBL9210890 | 0.80 | CA9 (0.74) | CHRNA7CA9MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9206649 | 0.79 | CHRNA7 (0.56) | CHRNA7CA9MAPTPTGS2FAAH | |
| SCHEMBL9278196 | 0.77 | PTGS2 (0.45) | MAPTPTGS2MARS1 | |
| SCHEMBL9201863 | 0.76 | PDE4B (0.51) | CHRNA7CA9ALDH1A1FAAHKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |