Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1394889 | 0.98 | SLC6A9 (0.42) | EGLN1SLC6A9POLBPDE4BALDH1A1 | |
| SCHEMBL20624199 | 0.94 | EGLN1 (0.36) | EGLN1SLC6A9POLBPDE4BKDM4E | |
| SCHEMBL7869921 | 0.94 | EGLN1 (0.39) | EGLN1SLC6A9POLBPDE4BALDH1A1 | |
| SCHEMBL12544369 | 0.92 | CYP2C19 (0.43) | ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7871400 | 0.92 | ALDH1A1 (0.40) | EGLN1POLBALDH1A1KDM4EMEN1 | |
| SCHEMBL16800534 | 0.91 | NOS1 (0.43) | EGLN1SLC6A9PDE4BALDH1A1GAA | |
| SCHEMBL29299528 | 0.91 | NOS1 (0.43) | EGLN1SLC6A9PDE4BALDH1A1GAA | |
| SCHEMBL22887713 | 0.90 | SLC6A9 (0.41) | EGLN1SLC6A9POLBPDE4BALDH1A1 | |
| SCHEMBL12747963 | 0.89 | CYP2C19 (0.41) | PDE4BALDH1A1GAAKDM4EMEN1 | |
| SCHEMBL25574097 | 0.89 | ALDH1A1 (0.45) | EGLN1SLC6A9ALDH1A1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5403572-A | Macrocyclic polyaza compounds containing 5 or 6 membered rings, process for producing them and pharmaceutical media containing them | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-04-04 | — | — | US | disclosed |
| EP-0352218-B1 | Macrocyclic polyaza compounds containing rings with 5 or 6 members, methods for their preparation and pharmaceutical compositions containing same | SCHERING AG (DE) | 1995-02-22 | — | — | EP | disclosed |
| US-5334371-A | Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI | SCHERING AKTIENGESELLSCHAFT (DE) | 1994-08-02 | — | — | US | disclosed |
| EP-0352218-A2 | Macrocyclic polyaza compounds containing rings with 5 or 6 members, methods for their preparation and pharmaceutical compositions containing same | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-01-24 | — | — | EP | disclosed |