Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 13/20 | 0.73 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.73 |
| ▸ | HTR7 | P34969 | 4/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.73 |
| ▸ | MPO | P05164 | 3/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.60 |
| ▸ | HTR6 | P50406 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9214152 | 0.94 | HTR1A (0.65) | HTR1ASLC6A4HTR7KCNH2MPO | |
| SCHEMBL9210187 | 0.89 | HTR1A (0.64) | HTR1ASLC6A4HTR7KCNH2HTR6 | |
| SCHEMBL4357142 | 0.87 | HTR1A (0.68) | HTR1ASLC6A4HTR7KCNH2MPO | |
| Hydrochloric Acid SCHEMBL9206187 | 0.87 | HTR1A (0.62) | HTR1ASLC6A4HTR7KCNH2HTR6 | |
| Hydrochloric Acid SCHEMBL4347864 | 0.86 | HTR1A (0.70) | HTR1ASLC6A4HTR7KCNH2MPO | |
| Hydrochloric Acid SCHEMBL4356376 | 0.86 | HTR1A (0.70) | HTR1ASLC6A4HTR7KCNH2MPO | |
| SCHEMBL9210900 | 0.86 | HTR1A (0.65) | HTR1ASLC6A4HTR7KCNH2HTR6 | |
| SCHEMBL27989611 | 0.85 | HTR1A (0.69) | HTR1AKCNH2HTR6 | |
| SCHEMBL9211546 | 0.85 | HTR2A (0.64) | HTR1A | |
| Hydrochloric Acid SCHEMBL9213478 | 0.85 | HTR1A (0.64) | HTR1ASLC6A4HTR7KCNH2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0345808-B1 | 1-Indolylalkyl-4-(substituted-pyridinyl)piperazines | BRISTOL MYERS SQUIBB CO (US) | 1995-01-11 | — | — | EP | claimed |
| US-4954502-A | Antidepressants | BRISTOL-MYERS SQUIBB COMPANY (US) | 1990-09-04 | — | — | US | claimed |
| EP-0345808-A1 | 1-Indolylalkyl-4-(substituted-pyridinyl)piperazines | Bristol-Myers Squibb Company (US) | 1989-12-13 | — | — | EP | claimed |