Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 10/20 | 0.35 |
| ▸ | PIM1 | P11309 | 6/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.34 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 4/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9206531 | 0.90 | ROCK1 (0.37) | ROCK1NOTUMPIM2PIM1CACNA1G | |
| SCHEMBL14218868 | 0.69 | NOTUM (0.50) | ROCK1NOTUMSLC6A2SLC6A4 | |
| SCHEMBL13663906 | 0.65 | BCHE (0.37) | ROCK1NOTUMCACNA1GCACNA1HCACNA1I | |
| SCHEMBL28298834 | 0.63 | NOTUM (0.55) | ROCK1NOTUMSLC6A2SLC6A4 | |
| SCHEMBL8860185 | 0.63 | MEN1 (0.34) | CACNA1GCACNA1HCACNA1IKDM4C | |
| SCHEMBL13078125 | 0.62 | ADORA3 (0.40) | ROCK1NOTUM | |
| SCHEMBL31302719 | 0.62 | NOTUM (0.49) | ROCK1NOTUMSLC6A2SLC6A4 | |
| SCHEMBL9311407 | 0.61 | HTR2C (0.40) | — | |
| SCHEMBL9501335 | 0.61 | CACNA1I (0.54) | ROCK1NOTUMCACNA1GCACNA1HCACNA1I | |
| SCHEMBL18681421 | 0.60 | NOTUM (0.55) | ROCK1NOTUMSLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0415103-B1 | 2,3-Dihydro-1-(pyridinylamino)-indoles, a process for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1995-02-01 | — | — | EP | disclosed |
| US-5296488-A | Method of using 2,3-dihydro-1-(pyridinylamino)-indoles as anticonvulsants and for the enhancement of memory | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-03-22 | — | — | US | disclosed |
| US-5179099-A | Analgesics | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-01-12 | — | — | US | disclosed |
| EP-0415103-A1 | 2,3-Dihydro-1-(pyridinylamino)-indoles, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-03-06 | — | — | EP | disclosed |