Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.35 |
| ▸ | TGFBR2 | P37173 | 4/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.34 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.33 |
| ▸ | CFD | P00746 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9206437 | 0.90 | ROCK1 (0.37) | ROCK1NOTUMCACNA1GCACNA1HCACNA1I | |
| SCHEMBL8860185 | 0.73 | MEN1 (0.34) | TGFBR1TGFBR2CACNA1GCACNA1HCACNA1I | |
| SCHEMBL9311407 | 0.72 | HTR2C (0.40) | LMNASMN1; SMN2 | |
| SCHEMBL14218868 | 0.69 | NOTUM (0.50) | ROCK1NOTUMSLC6A2SLC6A4SMN1; SMN2 | |
| SCHEMBL13663906 | 0.68 | BCHE (0.37) | ROCK1NOTUMCACNA1GCACNA1HCACNA1I | |
| SCHEMBL7480165 | 0.66 | TGFBR1 (0.35) | TGFBR1TGFBR2CFDLMNA | |
| Hydrochloric Acid SCHEMBL7484530 | 0.65 | TGFBR1 (0.34) | TGFBR1TGFBR2CFDLMNA | |
| SCHEMBL8860096 | 0.65 | HPGD (0.37) | NOTUMTGFBR1TGFBR2CFD | |
| SCHEMBL7608055 | 0.65 | TGFBR1 (0.38) | TGFBR1TGFBR2 | |
| SCHEMBL28298834 | 0.63 | NOTUM (0.55) | ROCK1NOTUMSLC6A2SLC6A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179821-B2 | Method of treating of demyelinating diseases or conditions | AVENTIS PHARMACEUTICALS INC. (US) | 2007-02-20 | — | — | US | disclosed |
| EP-0415103-B1 | 2,3-Dihydro-1-(pyridinylamino)-indoles, a process for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1995-02-01 | — | — | EP | disclosed |
| US-5296488-A | Method of using 2,3-dihydro-1-(pyridinylamino)-indoles as anticonvulsants and for the enhancement of memory | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-03-22 | — | — | US | disclosed |
| US-5179099-A | Analgesics | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-01-12 | — | — | US | disclosed |
| EP-0415103-A1 | 2,3-Dihydro-1-(pyridinylamino)-indoles, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-03-06 | — | — | EP | disclosed |