Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
| ▸ | PGR | P06401 | 1/20 | 0.55 |
| ▸ | RORA | P35398 | 1/20 | 0.55 |
| ▸ | RORC | P51449 | 1/20 | 0.55 |
| ▸ | RORB | Q92753 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | TOP2A | P11388 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9215327 | 0.96 | PGR (0.59) | PDE4APDE4BPDE4CPDE4DPGR | |
| SCHEMBL9208527 | 0.91 | ADORA3 (0.53) | PDE4APDE4BPDE4CPDE4DPGR | |
| SCHEMBL9209660 | 0.87 | LMNA (0.53) | PDE4APDE4BPDE4CPDE4DPGR | |
| SCHEMBL9197545 | 0.86 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DPGR | |
| SCHEMBL9208110 | 0.85 | PGR (0.58) | PDE4APDE4BPDE4CPDE4DPGR | |
| SCHEMBL9209945 | 0.84 | PGR (0.57) | PDE4APDE4BPDE4CPDE4DPGR | |
| Hydrochloric Acid SCHEMBL9214689 | 0.84 | PGR (0.57) | PDE4APDE4BPDE4CPDE4DPGR | |
| SCHEMBL9210569 | 0.84 | PGR (0.57) | PDE4APDE4BPDE4CPDE4DPGR | |
| Hydrochloric Acid SCHEMBL9206590 | 0.82 | PGR (0.56) | PDE4APDE4BPDE4CPDE4DPGR | |
| Hydrochloric Acid SCHEMBL9214838 | 0.82 | PGR (0.56) | PDE4APDE4BPDE4CPDE4DPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0386722-B1 | Imidazoquinolone derivatives | KYOWA HAKKO KOGYO KK (JP) | 1995-07-26 | — | — | EP | disclosed |
| US-4994468-A | Bronchodilators, antiallergens | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-02-19 | — | — | US | disclosed |
| EP-0386722-A1 | Imidazoquinolone derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1990-09-12 | — | — | EP | disclosed |