Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9214027 | 0.99 | CHRNB2 (0.44) | CHRNB2CHRNA4CHRNB4CHRNA3POLB | |
| Hydrochloric Acid SCHEMBL9206461 | 0.96 | HRH3 (0.45) | CHRNB2CHRNA4CHRNB4CHRNA3POLB | |
| Hydrochloric Acid SCHEMBL9208133 | 0.94 | TDP1 (0.44) | HRH3TDP1 | |
| SCHEMBL9206439 | 0.91 | ABCB1 (0.49) | CHRNB2CHRNA4CHRNB4CHRNA3POLB | |
| Hydrochloric Acid SCHEMBL9213140 | 0.90 | ABCB1 (0.48) | CHRNB2CHRNA4CHRNB4CHRNA3POLB | |
| Hydrochloric Acid SCHEMBL9206636 | 0.88 | ABCB1 (0.48) | CHRNB2CHRNA4CHRNB4CHRNA3POLB | |
| SCHEMBL9216836 | 0.85 | ABCB1 (0.51) | TDP1 | |
| Hydrochloric Acid SCHEMBL9207471 | 0.85 | DRD2 (0.43) | CHRNB2CHRNA4CHRNB4CHRNA3POLB | |
| Hydrochloric Acid SCHEMBL9215591 | 0.85 | ABCB1 (0.50) | TDP1 | |
| SCHEMBL9739808 | 0.84 | HRH3 (0.41) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | claimed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | claimed |
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| EP-0330052-B1 | Use of benzimidazoles for preparing a medicine with an anti-ischemial activity on the heart, and combinations with betablockers or bradycardics | THOMAE GMBH DR K (DE) | 1993-12-15 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0330052-A2 | Use of benzimidazoles for preparing a medicine with an anti-ischemial activity on the heart, and combinations with betablockers or bradycardics | Dr. Karl Thomae GmbH (DE) | 1989-08-30 | — | — | EP | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |