SCHEMBL920683

SCHEMBL920683

NC(=O)c1cccc(Oc2ccccc2)c1F

nearest known ligand 0.72

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CTNNB1 P35222 1/20 0.72
PARP10 Q53GL7 2/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
SIRT2 Q8IXJ6 1/20 0.51
SIRT1 Q96EB6 1/20 0.51
TDP1 Q9NUW8 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
BRD4 O60885 2/20 0.48
MEN1 O00255 1/20 0.46
MAPK1 P28482 1/20 0.46
KMT2A Q03164 1/20 0.46
IRAK4 Q9NWZ3 1/20 0.44
NPSR1 Q6W5P4 1/20 0.43
CHEK2 O96017 1/20 0.43
RAB9A P51151 1/20 0.42
SLC6A2 P23975 1/20 0.42
SLC6A4 P31645 1/20 0.42
SLC6A3 Q01959 1/20 0.42
ADRA2C P18825 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL921730 0.86 CTNNB1 (0.56) CTNNB1SMN1; SMN2TDP1L3MBTL1MEN1
Hydrochloric Acid SCHEMBL923514 0.85 CTNNB1 (0.54) CTNNB1SMN1; SMN2TDP1L3MBTL1MEN1
SCHEMBL27680126 0.84 CTNNB1 (1.00) CTNNB1PARP10SMN1; SMN2SIRT2SIRT1
SCHEMBL28876495 0.84 CTNNB1 (1.00) CTNNB1PARP10SMN1; SMN2SIRT2SIRT1
SCHEMBL5724 0.84 CTNNB1 (1.00) CTNNB1PARP10SMN1; SMN2SIRT2SIRT1
SCHEMBL923513 0.83 CTNNB1 (0.53) CTNNB1SMN1; SMN2TDP1L3MBTL1MEN1
SCHEMBL3691763 0.83 PARP10 (0.53) CTNNB1PARP10SMN1; SMN2SIRT2SIRT1
Hydrochloric Acid SCHEMBL50731 0.82 CTNNB1 (0.96) CTNNB1PARP10SMN1; SMN2SIRT2SIRT1
SCHEMBL28081666 0.82 CTNNB1 (0.96) CTNNB1PARP10SMN1; SMN2SIRT2SIRT1
Methyl Alcohol SCHEMBL8782982 0.81 CTNNB1 (0.93) CTNNB1PARP10SMN1; SMN2SIRT2SIRT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110483366-A Benzazole compounds and preparation method thereof, pharmaceutical composition and purposes INST MATERIA MEDICA CAMS 2019-11-22 CN disclosed
CN-106257976-A Human plasma kallikrein inhibitors 拜奥克里斯特制药公司 2016-12-28 CN disclosed
CN-101951771-A Composition for agricultural use for controlling or preventing plant diseases caused by plant pathogens SUMITOMO CHEMICAL CO 2011-01-19 CN disclosed
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
EP-2248423-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS Sumitomo Chemical Company, Limited (JP) 2010-11-10 EP disclosed
WO-2009110542-A1 ANILIDE COMPOUND AND USE THEREOF 住友化学株式会社 (JP) 2009-09-11 WO disclosed
WO-2009107764-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS 住友化学株式会社 (JP) 2009-09-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS WIZ, TST, NAT1 CTNNB1 2325/4885PARP10 4735/4885SMN1; SMN2 4796/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.