Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9205933 | 0.97 | LTA4H (0.35) | LTA4HHRH3KDM4EMAPK1ALDH1A1 | |
| SCHEMBL9214406 | 0.95 | ATM (0.37) | HRH3KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL9206564 | 0.94 | NPC1 (0.36) | LTA4HHRH3KDM4EMAPK1ALDH1A1 | |
| SCHEMBL9208761 | 0.93 | NPC1 (0.35) | LTA4HHRH3KDM4EMAPK1ALDH1A1 | |
| SCHEMBL9207422 | 0.89 | HRH3 (0.40) | LTA4HHRH3KDM4EALDH1A1LMNA | |
| SCHEMBL9208037 | 0.87 | HRH3 (0.37) | LTA4HHRH3KDM4EALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL9741774 | 0.86 | ALOX15 (0.45) | HRH3KDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL9213547 | 0.85 | LTA4H (0.37) | LTA4HHRH3KDM4EMAPK1ALDH1A1 | |
| SCHEMBL9739483 | 0.85 | LTA4H (0.42) | LTA4HKDM4EMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9215720 | 0.84 | ALOX15 (0.45) | KDM4EALDH1A1SMN1; SMN2ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |