Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | GHSR | Q92847 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9208037 | 0.97 | HRH3 (0.37) | HRH3MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL9216033 | 0.94 | ATM (0.39) | HRH3KDM4EALDH1A1ATMALOX15 | |
| SCHEMBL9208876 | 0.94 | HRH3 (0.36) | HRH3MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL9212975 | 0.93 | HRH3 (0.35) | HRH3MEN1KMT2AKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL9741774 | 0.90 | ALOX15 (0.45) | HRH3MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL9207563 | 0.89 | LTA4H (0.37) | HRH3MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL9215720 | 0.88 | ALOX15 (0.45) | KDM4EALDH1A1ATMKCNH2ALOX15 | |
| SCHEMBL9205933 | 0.87 | LTA4H (0.35) | HRH3MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL9209656 | 0.85 | ALOX15 (0.47) | KDM4EALDH1A1ATMKCNH2ALOX15 | |
| SCHEMBL9206630 | 0.85 | ALOX15 (0.43) | KDM4EALDH1A1KCNH2ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |