Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | DRD5 | P21918 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9217026 | 0.98 | MAPK1 (0.40) | MAPK1MAOALTA4HHTR2BSMN1; SMN2 | |
| SCHEMBL9215967 | 0.94 | HTR2B (0.38) | MAPK1HTR2BDRD2ALDH1A1 | |
| SCHEMBL9208812 | 0.92 | DRD2 (0.38) | MAPK1MAOALTA4HHTR2BSMN1; SMN2 | |
| SCHEMBL9209357 | 0.91 | DRD2 (0.37) | MAPK1LTA4HHTR2BSMN1; SMN2PKM | |
| SCHEMBL9213117 | 0.90 | MAPK1 (0.42) | MAPK1MAOALTA4HHTR2BSMN1; SMN2 | |
| SCHEMBL9210489 | 0.88 | HCRTR1 (0.44) | MAPK1HTR2BSMN1; SMN2DRD2LMNA | |
| SCHEMBL9215152 | 0.88 | MAPK1 (0.44) | MAPK1MAOALTA4HHTR2BSMN1; SMN2 | |
| SCHEMBL9207394 | 0.85 | HCRTR1 (0.44) | MAPK1HTR2BSMN1; SMN2PKMDRD2 | |
| SCHEMBL9207136 | 0.84 | HTR2B (0.39) | MAPK1HTR2BSMN1; SMN2DRD2LMNA | |
| SCHEMBL9213547 | 0.83 | LTA4H (0.37) | MAPK1LTA4HLMNAKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |