Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | PPID | Q08752 | 1/20 | 0.33 |
| ▸ | PPIG | Q13427 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9279576 | 0.89 | HTR2A (0.40) | ALDH1A1L3MBTL1KMT2ASMN1; SMN2HPGD | |
| SCHEMBL8341852 | 0.77 | UBE2M (0.42) | ALDH1A1KMT2AACHEKDM4E | |
| SCHEMBL8339190 | 0.69 | UBE2M (0.39) | — | |
| SCHEMBL8340911 | 0.67 | GCGR (0.42) | — | |
| SCHEMBL29221799 | 0.63 | ALDH1A1 (0.60) | ALDH1A1L3MBTL1LMNAMEN1KMT2A | |
| SCHEMBL3556571 | 0.62 | ALDH1A1 (0.62) | ALDH1A1L3MBTL1MEN1KMT2ARAB9A | |
| SCHEMBL8338757 | 0.62 | GRIN2B (0.54) | ALDH1A1L3MBTL1MEN1KMT2ARAB9A | |
| Hydrochloric Acid SCHEMBL10447095 | 0.61 | GRIN2B (0.53) | ALDH1A1L3MBTL1MEN1KMT2ARAB9A | |
| SCHEMBL24576001 | 0.60 | MEN1 (0.63) | ALDH1A1L3MBTL1LMNAMEN1KMT2A | |
| SCHEMBL31347382 | 0.59 | SMN1; SMN2 (0.51) | ALDH1A1L3MBTL1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0642498-A1 | NEW $i(N)-ARYL AND $i(N)-HETEROARYLUREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A:CHOLESTEROL ACYL TRANSFERASE (ACAT) | PFIZER INC. (US) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993024458-A1 | NEW N-ARYL AND N-HETEROARYLUREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A:CHOLESTEROL ACYL TRANSFERASE (ACAT) | PFIZER INC. (US) | 1993-12-09 | — | — | WO | disclosed |