Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | CTSL | P07711 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | FAAH | O00519 | 1/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14441237 | 0.93 | MAPT (0.69) | MAPTALDH1A1GAAHPGDKMT2A | |
| SCHEMBL9205145 | 0.87 | KMT2A (0.62) | MAPTALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL9203635 | 0.87 | MAPT (0.64) | MAPTALDH1A1GAACTSLHPGD | |
| SCHEMBL14441255 | 0.86 | PTGS1 (0.59) | MAPTALDH1A1CTSLHPGDKMT2A | |
| SCHEMBL14441242 | 0.86 | RAB9A (0.62) | MAPTALDH1A1GAAHPGDKMT2A | |
| SCHEMBL9207220 | 0.84 | MEN1 (0.66) | MAPTALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL1520454 | 0.84 | MAPT (0.67) | MAPTALDH1A1GAACTSLHPGD | |
| SCHEMBL31447965 | 0.83 | MAPT (0.70) | MAPTALDH1A1GAAHPGDKMT2A | |
| SCHEMBL28374383 | 0.82 | MAPT (0.56) | MAPTALDH1A1GAAHPGDKMT2A | |
| SCHEMBL12371556 | 0.82 | MAPT (0.78) | MAPTALDH1A1GAACTSLHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0475755-B1 | 3-Aryl-4(3H)quinazolinone CCK antagonists and pharmaceutical formulations thereof | LILLY CO ELI (US) | 1995-09-27 | — | — | EP | disclosed |
| US-5196427-A | Gastrointestinal and central nervous system disorders; hormone inhibitors | ELI LILLY AND COMPANY (US) | 1993-03-23 | — | — | US | disclosed |
| EP-0475755-A1 | 3-Aryl-4(3H)quinazolinone CCK antagonists and pharmaceutical formulations thereof | ELI LILLY AND COMPANY (US) | 1992-03-18 | — | — | EP | disclosed |
| US-5075313-A | For bindign to cholecystokinin receptors | ELI LILLY AND COMPANY (US) | 1991-12-24 | — | — | US | disclosed |