Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.61 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.60 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | CDK2 | P24941 | 1/20 | 0.57 |
| ▸ | FAAH | O00519 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.54 |
| ▸ | MPO | P05164 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9208268 | 0.92 | MEN1 (0.66) | MEN1KMT2AMAPTPTGS1PTGS2 | |
| SCHEMBL14441255 | 0.86 | PTGS1 (0.59) | MEN1KMT2AMAPTHCAR2PTGS1 | |
| SCHEMBL9208939 | 0.84 | MAPT (0.62) | MEN1KMT2AMAPTPTGS1PTGS2 | |
| 5-Methoxytryptamine SCHEMBL31454739 | 0.81 | TRPM8 (0.74) | MEN1KMT2AMAPTPTGS1PTGS2 | |
| SCHEMBL28409511 | 0.79 | PTGS2 (0.78) | MEN1KMT2APTGS1PTGS2MTNR1A | |
| SCHEMBL10670286 | 0.79 | MTNR1A (0.71) | MEN1KMT2AMAPTMTNR1AMTNR1B | |
| SCHEMBL3024961 | 0.79 | KDM4E (0.75) | MEN1KMT2AMAPTMTNR1AMTNR1B | |
| SCHEMBL9203635 | 0.78 | MAPT (0.64) | MEN1KMT2AMAPTPOLBKDM4E | |
| SCHEMBL9054622 | 0.78 | MTNR1A (0.66) | MEN1KMT2AMAPTMTNR1AMTNR1B | |
| SCHEMBL5207887 | 0.78 | KDM4E (0.60) | MEN1KMT2AMAPTMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0475755-B1 | 3-Aryl-4(3H)quinazolinone CCK antagonists and pharmaceutical formulations thereof | LILLY CO ELI (US) | 1995-09-27 | — | — | EP | disclosed |
| US-5196427-A | Gastrointestinal and central nervous system disorders; hormone inhibitors | ELI LILLY AND COMPANY (US) | 1993-03-23 | — | — | US | disclosed |
| EP-0475755-A1 | 3-Aryl-4(3H)quinazolinone CCK antagonists and pharmaceutical formulations thereof | ELI LILLY AND COMPANY (US) | 1992-03-18 | — | — | EP | disclosed |
| US-5075313-A | For bindign to cholecystokinin receptors | ELI LILLY AND COMPANY (US) | 1991-12-24 | — | — | US | disclosed |