Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29123756 | 0.85 | CA2 (0.34) | CA2TMEM97SIGMAR1 | |
| SCHEMBL14307903 | 0.84 | CYP2C19 (0.41) | CA2TMEM97SIGMAR1 | |
| SCHEMBL3952930 | 0.84 | CYP2C19 (0.41) | CA2TMEM97SIGMAR1 | |
| SCHEMBL4918516 | 0.81 | CA2 (0.49) | CA2KDM4EMAPTTMEM97SIGMAR1 | |
| SCHEMBL4501663 | 0.81 | CA2 (0.49) | CA2KDM4EMAPTTMEM97SIGMAR1 | |
| SCHEMBL3376386 | 0.81 | CA2 (0.49) | CA2KDM4EMAPTTMEM97SIGMAR1 | |
| SCHEMBL28866445 | 0.81 | CA2 (0.33) | CA2 | |
| SCHEMBL9077337 | 0.79 | CA2 (0.34) | CA2SIGMAR1 | |
| SCHEMBL29983676 | 0.77 | PDK1 (0.39) | CA2TMEM97SIGMAR1 | |
| SCHEMBL29984022 | 0.77 | PDK1 (0.39) | CA2TMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0687263-A1 | NOVEL PROCESS FOR -i(TRANS)-6- 2-(SUBSTITUTED-PYRROL-1-YL)ALKYL]PYRAN-2-ONE INHIBITORS OF CHOLESTEROL SYNTHESIS | WARNER LAMBERT CO (US) | 1995-12-20 | — | — | EP | claimed |
| WO-1994020492-A1 | NOVEL PROCESS FOR TRANS-6-[2-(SUBSTITUTED-PYRROL-1-YL)ALKYL]PYRAN-2-ONE INHIBITORS OF CHOLESTEROL SYNTHESIS | WARNER-LAMBERT COMPANY (US) | 1994-09-15 | — | — | WO | claimed |