Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | HCN4 | Q9Y3Q4 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9741774 | 0.94 | ALOX15 (0.45) | ALOX15ALDH1A1KDM4ETSHRCASP1 | |
| SCHEMBL9215720 | 0.94 | ALOX15 (0.45) | ALOX15ALDH1A1KDM4ETSHRCASP1 | |
| SCHEMBL9216033 | 0.90 | ATM (0.39) | ALOX15ALDH1A1KDM4ETSHRCASP1 | |
| SCHEMBL9206630 | 0.89 | ALOX15 (0.43) | ALOX15ALDH1A1KDM4ETSHRCASP1 | |
| Hydrochloric Acid SCHEMBL9740340 | 0.88 | ALOX15 (0.43) | ALOX15ALDH1A1KDM4ETSHRCASP1 | |
| Hydrochloric Acid SCHEMBL9740263 | 0.88 | ALOX15 (0.42) | ALOX15ALDH1A1KDM4ETSHRCASP1 | |
| Hydrochloric Acid SCHEMBL9739549 | 0.88 | ALOX15 (0.42) | ALOX15ALDH1A1KDM4ETSHRCASP1 | |
| SCHEMBL9214406 | 0.86 | ATM (0.37) | ALDH1A1KDM4ESMN1; SMN2ATMDRD4 | |
| SCHEMBL9207422 | 0.85 | HRH3 (0.40) | ALOX15ALDH1A1KDM4ETSHRCASP1 | |
| SCHEMBL9208037 | 0.84 | HRH3 (0.37) | ALOX15ALDH1A1KDM4ETSHRCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |