Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.31 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.31 |
| ▸ | NAMPT | P43490 | 3/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9217244 | 1.00 | GAA (0.35) | GAASLC6A2SLC6A4P2RX7NPY5R | |
| SCHEMBL9212001 | 0.91 | NPY5R (0.34) | GAASLC6A2SLC6A4P2RX7NPY5R | |
| SCHEMBL9217487 | 0.91 | NPY5R (0.34) | GAASLC6A2SLC6A4P2RX7NPY5R | |
| SCHEMBL9212826 | 0.89 | MAPK1 (0.38) | GAASLC6A2SLC6A4P2RX7SMN1; SMN2 | |
| SCHEMBL9211996 | 0.87 | MAPK1 (0.41) | GAASLC6A2SLC6A4P2RX7SMN1; SMN2 | |
| SCHEMBL9212254 | 0.87 | MAPK1 (0.41) | GAASLC6A2SLC6A4P2RX7SMN1; SMN2 | |
| SCHEMBL9219317 | 0.85 | L3MBTL1 (0.37) | GAASMN1; SMN2NAMPTLMNATSHR | |
| SCHEMBL9219315 | 0.85 | L3MBTL1 (0.37) | GAASMN1; SMN2NAMPTLMNATSHR | |
| SCHEMBL9216674 | 0.82 | SLC6A2 (0.36) | GAASLC6A2SLC6A4P2RX7SMN1; SMN2 | |
| SCHEMBL9211543 | 0.82 | P2RX7 (0.34) | GAASLC6A2SLC6A4P2RX7SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510028-B1 | THIOFORMAMIDE DERIVATIVES | RHONE POULENC RORER SA (FR) | 1995-03-15 | — | — | EP | claimed |
| US-5364853-A | Treatment of disorders associated with vascular, respiratory, gastrointestinal tract, urinary bladder or uterus smooth muscle contraction | RHONE-POULENC RORER LIMITED (GB) | 1994-11-15 | — | — | US | claimed |
| EP-0510028-B1 | THIOFORMAMIDE DERIVATIVES | RHONE POULENC RORER SA (FR) | 1995-03-15 | — | — | EP | disclosed |
| WO-1991010652-A1 | THIOFORMAMIDE DERIVATIVES | RHONE-POULENC RORER S.A. (FR) | 1991-07-25 | — | — | WO | disclosed |