Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.44 |
| ▸ | HTR2B | P41595 | 5/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9210043 | 0.99 | DRD2 (0.44) | DRD2HTR2BHCRTR1HCRTR2SMN1; SMN2 | |
| SCHEMBL9207394 | 0.94 | HCRTR1 (0.44) | DRD2HTR2BHCRTR1HCRTR2SMN1; SMN2 | |
| SCHEMBL9210489 | 0.92 | HCRTR1 (0.44) | DRD2HTR2BHCRTR1HCRTR2SMN1; SMN2 | |
| SCHEMBL9206641 | 0.92 | MAPK1 (0.41) | DRD2HTR2BSMN1; SMN2CHRNB2CHRNA4 | |
| SCHEMBL9214809 | 0.91 | MAPK1 (0.41) | DRD2HTR2BHCRTR1HCRTR2SMN1; SMN2 | |
| SCHEMBL9216985 | 0.89 | HTR2B (0.45) | DRD2HTR2BHCRTR1HCRTR2SMN1; SMN2 | |
| SCHEMBL9209357 | 0.89 | DRD2 (0.37) | DRD2HTR2BSMN1; SMN2CHRNB2CHRNA4 | |
| SCHEMBL9208812 | 0.88 | DRD2 (0.38) | DRD2HTR2BSMN1; SMN2DRD3LMNA | |
| SCHEMBL9215152 | 0.85 | MAPK1 (0.44) | DRD2HTR2BHCRTR1HCRTR2SMN1; SMN2 | |
| SCHEMBL9216928 | 0.83 | HCRTR1 (0.41) | HCRTR1HCRTR2SMN1; SMN2MAPTHCN4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |