Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 7/20 | 0.45 |
| ▸ | DRD2 | P14416 | 4/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HCN4 | Q9Y3Q4 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9207394 | 0.95 | HCRTR1 (0.44) | HTR2BDRD2HCRTR1HCRTR2BCHE | |
| SCHEMBL9210489 | 0.94 | HCRTR1 (0.44) | HTR2BDRD2HCRTR1HCRTR2BCHE | |
| SCHEMBL9207136 | 0.91 | HTR2B (0.39) | HTR2BDRD2HCRTR1HCRTR2BCHE | |
| SCHEMBL9210043 | 0.90 | DRD2 (0.44) | HTR2BDRD2HCRTR1HCRTR2HTR1A | |
| SCHEMBL9210258 | 0.89 | DRD2 (0.44) | HTR2BDRD2HCRTR1HCRTR2LMNA | |
| SCHEMBL9215967 | 0.87 | HTR2B (0.38) | HTR2BDRD2ACHEHTR1AALDH1A1 | |
| SCHEMBL9215152 | 0.86 | MAPK1 (0.44) | HTR2BDRD2HCRTR1HCRTR2LMNA | |
| SCHEMBL9213117 | 0.85 | MAPK1 (0.42) | HTR2BDRD2HCRTR1HCRTR2LMNA | |
| SCHEMBL9217026 | 0.83 | MAPK1 (0.40) | HTR2BDRD2HCRTR1HCRTR2LMNA | |
| SCHEMBL9207626 | 0.82 | MAPK1 (0.38) | HTR2BDRD2HCRTR1HCRTR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |