Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.41 |
| ▸ | HCN4 | Q9Y3Q4 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9213551 | 0.95 | HCRTR1 (0.42) | HCRTR1HCRTR2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL9216368 | 0.91 | KDM2B (0.36) | HCRTR1HCRTR2KCNH2LMNAKDM2B | |
| SCHEMBL9206763 | 0.88 | LTA4H (0.36) | HCRTR1HCRTR2LMNAKDM2B | |
| SCHEMBL9215744 | 0.86 | KDM2B (0.37) | HCRTR1HCRTR2SLC6A4KCNH2LMNA | |
| SCHEMBL9210043 | 0.84 | DRD2 (0.44) | HCRTR1HCRTR2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL9206630 | 0.83 | ALOX15 (0.43) | CHRNB2CHRNB4CHRNA3CHRNA4HCN4 | |
| SCHEMBL9213547 | 0.83 | LTA4H (0.37) | HCRTR1HCRTR2LMNAKDM2B | |
| SCHEMBL9210258 | 0.83 | DRD2 (0.44) | HCRTR1HCRTR2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL9207394 | 0.83 | HCRTR1 (0.44) | HCRTR1HCRTR2HCN4MAPTCYP3A4 | |
| Hydrochloric Acid SCHEMBL9740340 | 0.83 | ALOX15 (0.43) | CHRNB2CHRNB4CHRNA3CHRNA4HCN4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |