Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | BRD4 | O60885 | 1/20 | 0.56 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.56 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.56 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | CCR2 | P41597 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29023902 | 0.84 | POLB (1.00) | POLBHTTALDH1A1PKMBRD4 | |
| SCHEMBL29967435 | 0.84 | POLB (1.00) | POLBHTTALDH1A1PKMBRD4 | |
| SCHEMBL30209700 | 0.82 | POLB (0.83) | POLBHTTALDH1A1PKMBRD4 | |
| SCHEMBL16863131 | 0.81 | POLB (0.67) | POLBHTTALDH1A1PKMBRD4 | |
| SCHEMBL5560379 | 0.80 | POLB (0.65) | POLBHTTALDH1A1PKMBRD4 | |
| SCHEMBL1471970 | 0.79 | POLB (0.76) | POLBHTTALDH1A1PKMPSMB1 | |
| SCHEMBL5252456 | 0.78 | ALDH1A1 (0.64) | POLBALDH1A1KDM4ELMNAKMT2A | |
| SCHEMBL7770299 | 0.77 | MEN1 (0.71) | POLBHTTALDH1A1PKMBRD4 | |
| SCHEMBL6220974 | 0.77 | ALDH1A1 (0.58) | POLBALDH1A1BRD4KDM4ELMNA | |
| SCHEMBL4771765 | 0.77 | HDAC3 (0.53) | ALDH1A1BRD4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0532239-B1 | Benzenesulphonamide derivatives as 5-lipoxygenase inhibitors | ZENECA LTD (GB) | 1995-12-13 | — | — | EP | disclosed |
| US-5403857-A | Benzenesulphonamide derivatives having 5-lipoxygenase inhibitory activity | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-04-04 | — | — | US | disclosed |
| US-5314891-A | Lipoxygenase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-05-24 | — | — | US | disclosed |
| EP-0532239-A1 | Benzenesulphonamide derivatives as 5-lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1993-03-17 | — | — | EP | disclosed |