Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TOP1 | P11387 | 8/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9668111 | 0.92 | KDM4E (0.55) | KDM4EKCNH2ALDH1A1TOP1HPGD | |
| SCHEMBL9148013 | 0.88 | KDM4E (0.60) | KDM4EKCNH2ALDH1A1POLBCHRM2 | |
| SCHEMBL9215533 | 0.83 | ALDH1A1 (0.54) | KDM4EKCNH2ALDH1A1POLBCHRM2 | |
| SCHEMBL9668418 | 0.83 | HSD17B10 (0.48) | KDM4EKCNH2ALDH1A1CYP2C9HPGD | |
| SCHEMBL9213820 | 0.83 | CYP3A4 (0.39) | KDM4EKCNH2ALDH1A1POLBCHRM2 | |
| SCHEMBL9217114 | 0.82 | CYP3A4 (0.39) | KDM4EKCNH2ALDH1A1POLBCHRM2 | |
| SCHEMBL9668463 | 0.80 | ALDH1A1 (0.55) | KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9209326 | 0.80 | KDM4E (0.42) | KDM4EKCNH2ALDH1A1POLBCHRM2 | |
| SCHEMBL9147046 | 0.79 | KDM4E (0.53) | KDM4EKCNH2ALDH1A1POLBCHRM2 | |
| SCHEMBL9667565 | 0.79 | KDM4E (0.72) | KDM4EKCNH2ALDH1A1POLBTOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0388298-B1 | Derivatives of pyridone carboxylic acids substituted by an azetidine, their preparation and their use as medicines | ESTEVE LABOR DR (ES) | 1995-06-21 | — | — | EP | claimed |