Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 4/20 | 0.56 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.44 |
| ▸ | APOB | P04114 | 1/20 | 0.44 |
| ▸ | MTTP | P55157 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8882285 | 0.87 | TBXAS1 (0.62) | TBXA2RTBXAS1HDAC8PTGS2EGFR | |
| SCHEMBL8882282 | 0.87 | TBXAS1 (0.62) | TBXA2RTBXAS1HDAC8PTGS2EGFR | |
| SCHEMBL8884784 | 0.83 | TBXA2R (0.58) | TBXA2RTBXAS1HDAC8PTGS2EGFR | |
| SCHEMBL8884795 | 0.83 | TBXA2R (0.58) | TBXA2RTBXAS1HDAC8PTGS2EGFR | |
| SCHEMBL9203595 | 0.82 | TBXAS1 (0.70) | TBXA2RTBXAS1HDAC8PTGS2EGFR | |
| SCHEMBL8883506 | 0.82 | TBXAS1 (0.85) | TBXA2RTBXAS1 | |
| SCHEMBL8883511 | 0.82 | TBXAS1 (0.85) | TBXA2RTBXAS1 | |
| SCHEMBL9206563 | 0.78 | CA1 (0.48) | TBXA2RTBXAS1HDAC8ALDH1A1CYP1A2 | |
| SCHEMBL10406192 | 0.76 | TBXA2R (0.52) | TBXA2RTBXAS1HDAC8ALDH1A1NR1H2 | |
| SCHEMBL8882775 | 0.75 | GRIA2 (0.55) | EGFRALDH1A1NR1H2GRIA2APOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0397044-B1 | Arylsulfonamides, medicines containing these compounds and process for their preparation | THOMAE GMBH DR K (DE) | 1995-12-27 | — | — | EP | disclosed |
| EP-0397044-A2 | Arylsulfonamides, medicines containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1990-11-14 | — | — | EP | disclosed |