Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 3/20 | 0.44 |
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
| ▸ | CA7 | P43166 | 3/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA4 | P22748 | 2/20 | 0.44 |
| ▸ | CA5A | P35218 | 2/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9214625 | 0.87 | KDM4E (0.56) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL30689500 | 0.84 | KDM4E (0.49) | KDM4EALDH1A1HSD17B10TSHRKMT2A | |
| SCHEMBL9215376 | 0.83 | NPC1 (0.52) | KDM4EALDH1A1HSD17B10KMT2AHPGD | |
| SCHEMBL24933225 | 0.80 | EPHA2 (0.58) | EPHA2PDK1ERBB2EPHB4 | |
| SCHEMBL25539657 | 0.80 | EPHA2 (0.46) | EPHA2PDK1ERBB2EPHB4 | |
| SCHEMBL1852171 | 0.79 | PDK1 (0.51) | KMT2AEPHA2PDK1ERBB2EPHB4 | |
| SCHEMBL5297191 | 0.79 | EPHA2 (0.43) | EPHA2PDK1ERBB2EPHB4 | |
| SCHEMBL5292472 | 0.79 | EPHA2 (0.43) | EPHA2PDK1ERBB2EPHB4 | |
| SCHEMBL1473383 | 0.79 | EPHA2 (0.43) | EPHA2PDK1ERBB2EPHB4 | |
| SCHEMBL5294746 | 0.78 | KDM4E (0.51) | KDM4EMAPTEPHA2PDK1ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0411912-B1 | Coumarin derivatives, their preparation and their use in the treatment of cerebrovascular disorders | SANKYO CO (JP) | 1995-04-19 | — | — | EP | disclosed |
| EP-0411912-A2 | Coumarin derivatives, their preparation and their use in the treatment of cerebrovascular disorders | Sankyo Company Limited (JP) | 1991-02-06 | — | — | EP | disclosed |