Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHCR7 | Q9UBM7 | 3/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 11/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.43 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9214060 | 0.93 | DHCR7 (0.48) | DHCR7ABCB1KDM4ETDP1MAPT | |
| SCHEMBL9211699 | 0.89 | KDM2B (0.44) | DHCR7ABCB1KDM4ETDP1KDM2B | |
| Hydrochloric Acid SCHEMBL9206759 | 0.87 | DHCR7 (0.64) | DHCR7ABCB1KDM4ETDP1ABCG2 | |
| Hydrochloric Acid SCHEMBL9215875 | 0.86 | ABCB1 (0.54) | DHCR7ABCB1ABCG2 | |
| Hydrochloric Acid SCHEMBL9216467 | 0.84 | DHCR7 (0.58) | DHCR7ABCB1KDM4ETDP1ABCG2 | |
| SCHEMBL9213740 | 0.81 | ABCB1 (0.48) | DHCR7ABCB1 | |
| Hydrochloric Acid SCHEMBL9205960 | 0.81 | DHCR7 (0.61) | DHCR7ABCB1KDM4ETDP1ABCG2 | |
| SCHEMBL9213630 | 0.81 | ABCB1 (0.53) | DHCR7ABCB1ABCG2 | |
| SCHEMBL9207118 | 0.81 | HCN4 (0.46) | DHCR7ABCB1MAPTKDM2B | |
| SCHEMBL9214620 | 0.80 | ABCB1 (0.52) | DHCR7ABCB1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |