Sugi Predict

Sugi Predict / Compounds / SCHEMBL9211792

SCHEMBL9211792

SCHEMBL9211792

COCC(O)CNC(=O)OCc1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 1/20 0.56
▸ SMN1; SMN2 Q16637 1/20 0.56
▸ MAPT P10636 2/20 0.51
▸ L3MBTL1 Q9Y468 2/20 0.50
▸ HTT P42858 1/20 0.50
▸ ALDH1A1 P00352 1/20 0.50
▸ SYK P43405 1/20 0.49
▸ CTSS P25774 4/20 0.47
▸ CTSL P07711 3/20 0.47
▸ NPC1 O15118 1/20 0.47
▸ RAB9A P51151 1/20 0.47
▸ CTSK P43235 3/20 0.46
▸ CTSB P07858 1/20 0.46
▸ ITGB3 P05106 1/20 0.46
▸ ITGA2B P08514 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5019087 0.88 LMNA (0.61) LMNASMN1; SMN2L3MBTL1HTTALDH1A1
SCHEMBL20640801 0.87 LMNA (0.57) LMNASMN1; SMN2HTTALDH1A1SYK
SCHEMBL15691161 0.86 LMNA (0.50) LMNASMN1; SMN2HTTALDH1A1SYK
SCHEMBL5218083 0.85 SYK (0.57) LMNASMN1; SMN2MAPTL3MBTL1HTT
SCHEMBL30642172 0.84 LMNA (0.51) LMNASMN1; SMN2MAPTL3MBTL1HTT
SCHEMBL4549789 0.84 LMNA (0.55) LMNASMN1; SMN2MAPTL3MBTL1HTT
SCHEMBL15686276 0.84 LMNA (0.55) LMNASMN1; SMN2MAPTL3MBTL1HTT
SCHEMBL5885684 0.84 ALDH1A1 (0.60) MAPTL3MBTL1ALDH1A1ITGB3ITGA2B
SCHEMBL27268626 0.84 LMNA (0.54) LMNASMN1; SMN2HTTALDH1A1SYK
SCHEMBL12067897 0.84 LMNA (0.56) LMNASMN1; SMN2HTTALDH1A1SYK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10662185-B2 Amino-substituted imidazo[1,2-A] pyridinecarboxamides and their use BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2020-05-26 — — US disclosed
US-20190248783-A9 AMINO-SUBSTITUTED IMIDAZO[1,2-A] PYRIDINECARBOXAMIDES AND THEIR USE BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2019-08-15 — — US disclosed
US-20170182014-A1 AMINO-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINECARBOXAMIDES AND THEIR USE BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-06-29 — — US disclosed
US-20170182014-A1 AMINO-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINECARBOXAMIDES AND THEIR USE BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-06-29 — — US disclosed
US-9624214-B2 Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-04-18 — — US disclosed
US-9624214-B2 Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-04-18 — — US disclosed
US-20150274719-A1 AMINO-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINECARBOXAMIDES AND THEIR USE BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2015-10-01 — — US disclosed
US-9126998-B2 Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use Bayer Pharma AG (DE) 2015-09-08 — — US disclosed
US-9126998-B2 Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use Bayer Pharma AG (DE) 2015-09-08 — — US disclosed
US-20140179672-A1 Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2014-06-26 — — US disclosed
US-20140128372-A1 Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2014-05-08 — — US disclosed
US-20140128372-A1 Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2014-05-08 — — US disclosed
EP-0425209-B1 Naphthyloxazolidone derivatives TANABE SEIYAKU CO (JP) 1995-05-10 — — EP disclosed
EP-0642498-A1 NEW $i(N)-ARYL AND $i(N)-HETEROARYLUREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A:CHOLESTEROL ACYL TRANSFERASE (ACAT) PFIZER INC. (US) 1995-03-15 — — EP disclosed
US-5332754-A Antidepressant TANABE SEIYAKU CO., LTD. (JP) 1994-07-26 — — US disclosed
US-5182296-A Antidepressants TANABE SEIYAKY CO., LTD. (JP) 1993-01-26 — — US disclosed
EP-0425209-A2 Naphthyloxazolidone derivatives TANABE SEIYAKU CO., LTD. (JP) 1991-05-02 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140128372-A1 Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use AADAC, TNNI3, PAICS LMNA 252/4885SMN1; SMN2 1332/4885MAPT 4608/4885
US-20140179672-A1 Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use AADAC, TNNI3, PAICS LMNA 252/4885SMN1; SMN2 1332/4885MAPT 4608/4885
US-20190248783-A9 AMINO-SUBSTITUTED IMIDAZO[1,2-A] PYRIDINECARBOXAMIDES AND THEIR USE AADAC, TNNI3, PAICS LMNA 252/4885SMN1; SMN2 1332/4885MAPT 4608/4885
US-10662185-B2 Amino-substituted imidazo[1,2-A] pyridinecarboxamides and their use AADAC, TNNI3, TNNT2 LMNA 330/4885SMN1; SMN2 1459/4885MAPT 4680/4885
US-20150274719-A1 AMINO-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINECARBOXAMIDES AND THEIR USE AADAC, TNNI3, PAICS LMNA 252/4885SMN1; SMN2 1332/4885MAPT 4608/4885
US-20170182014-A1 AMINO-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINECARBOXAMIDES AND THEIR USE AADAC, TNNI3, PAICS LMNA 252/4885SMN1; SMN2 1332/4885MAPT 4608/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.