Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 3/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRE | P78334 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.39 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.39 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.39 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.39 |
| ▸ | SLC6A1 | P30531 | 4/20 | 0.38 |
| ▸ | SLC6A11 | P48066 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28296473 | 0.82 | GABRA5 (0.40) | GABRA5GABRB2TSHRGABRA1GABRA4 | |
| SCHEMBL584094 | 0.78 | — | — | |
| SCHEMBL1161879 | 0.78 | — | — | |
| SCHEMBL12699753 | 0.78 | — | — | |
| SCHEMBL6076974 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL3911969 | 0.76 | CHRNB2 (0.52) | GABRA5GABRB2TSHRGABRA1GABRA4 | |
| Hydrochloric Acid SCHEMBL17364117 | 0.76 | CHRNB2 (0.52) | GABRA5GABRB2TSHRGABRA1GABRA4 | |
| Hydrochloric Acid SCHEMBL594534 | 0.76 | CHRNB2 (0.52) | GABRA5GABRB2TSHRGABRA1GABRA4 | |
| Methane SCHEMBL10516513 | 0.76 | CHRNB2 (0.52) | GABRA5GABRB2TSHRGABRA1GABRA4 | |
| SCHEMBL1415306 | 0.74 | HRH3 (0.41) | GABRA5GABRB2TSHRGABRA1GABRA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0508549-B1 | New triazolopyrimidine and pyrazolopyrimidine derivatives useful for treating cachexia | SANKYO CO (JP) | 1995-04-26 | — | — | EP | disclosed |
| EP-0347252-B1 | METHOD OF TREATING CACHEXIA AND CERTAIN NEW COMPOUNDS FOR USE IN THIS METHOD | SANKYO COMPANY LIMITED (JP) | 1993-05-05 | — | — | EP | disclosed |
| EP-0508549-A2 | New triazolopyrimidine and pyrazolopyrimidine derivatives useful for treating cachexia | SANKYO COMPANY LIMITED (JP) | 1992-10-14 | — | — | EP | disclosed |
| US-5086057-A | METHOD OF TREATING CACHEXIA AND CERTAIN NEW COMPOUNDS FOR USE IN THIS METHOD | SANKYO COMPANY LIMITED (JP) | 1992-02-04 | — | — | US | disclosed |
| US-5055479-A | For enhancing activity of lipoprotein lipase enzymes | SANKYO COMPANY, LIMITED (JP) | 1991-10-08 | — | — | US | disclosed |