Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9212320 | 0.77 | NOTUM (0.44) | NOTUMMEN1KMT2AP2RX4BCHE | |
| SCHEMBL28550204 | 0.76 | KDM4E (0.42) | NOTUMMEN1KMT2AP2RX4CNR2 | |
| SCHEMBL9687940 | 0.75 | NOTUM (0.43) | NOTUMMEN1KMT2AP2RX4BCHE | |
| SCHEMBL14543698 | 0.74 | NOTUM (0.64) | NOTUMDRD2 | |
| SCHEMBL8265211 | 0.70 | NOTUM (0.43) | NOTUMMEN1KMT2ACNR2ALDH1A1 | |
| SCHEMBL14543732 | 0.69 | PRKACA (0.47) | NOTUMMEN1KMT2AP2RX4P2RY1 | |
| SCHEMBL26517033 | 0.69 | NOTUM (0.49) | NOTUMMEN1KMT2AP2RX4ALDH1A1 | |
| SCHEMBL28793814 | 0.68 | NOTUM (0.44) | NOTUMMEN1KMT2AP2RY1CNR2 | |
| SCHEMBL14412436 | 0.68 | NOTUM (0.59) | NOTUMDRD2 | |
| SCHEMBL3695799 | 0.67 | KDM1A (0.44) | NOTUMMEN1KMT2ABCHEP2RY1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0511879-B1 | Pyrazine derivatives | OTSUKA PHARMA CO LTD (JP) | 1995-03-22 | — | — | EP | disclosed |
| EP-0511879-A1 | Pyrazine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-04 | — | — | EP | disclosed |