Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | PRKACG | P22612 | 1/20 | 0.47 |
| ▸ | PRKACB | P22694 | 1/20 | 0.47 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.46 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14543698 | 0.81 | NOTUM (0.64) | HTTNOTUM | |
| SCHEMBL28162635 | 0.79 | PRKACA (0.45) | PRKACAPRKACGPRKACBP2RY1CACNA1G | |
| SCHEMBL9326653 | 0.78 | PRKACA (0.59) | PRKACAPRKACGPRKACBP2RY1CACNA1G | |
| SCHEMBL27835989 | 0.77 | CPS1 (0.41) | PRKACAPRKACGPRKACBP2RY1CACNA1G | |
| SCHEMBL8479255 | 0.77 | ALDH1A1 (0.50) | PRKACAPRKACGPRKACBP2RY1CACNA1G | |
| SCHEMBL27765328 | 0.73 | CACNA1G (0.42) | PRKACAPRKACGPRKACBP2RY1CACNA1G | |
| SCHEMBL8265211 | 0.73 | NOTUM (0.43) | ALDH1A1NOTUMTSHRSMN1; SMN2MEN1 | |
| SCHEMBL8263920 | 0.73 | POLB (0.38) | CACNA1GALDH1A1NOTUMPOLBCYP2C9 | |
| SCHEMBL27853991 | 0.73 | MGLL (0.44) | ALDH1A1HTTNOTUM | |
| SCHEMBL28793814 | 0.72 | NOTUM (0.44) | PRKACAPRKACGPRKACBP2RY1CACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |