Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | PRKACG | P22612 | 1/20 | 0.43 |
| ▸ | PRKACB | P22694 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9687940 | 0.87 | NOTUM (0.43) | NOTUMPRKACAPRKACGPRKACBMEN1 | |
| SCHEMBL10246760 | 0.83 | NOTUM (0.64) | NOTUMPRKACAPRKACGPRKACBSLC6A2 | |
| SCHEMBL14230009 | 0.79 | NOTUM (0.48) | NOTUMPRKACAPRKACGPRKACBMEN1 | |
| SCHEMBL14200389 | 0.77 | NOTUM (0.46) | NOTUMPRKACAPRKACGPRKACBMEN1 | |
| SCHEMBL9212313 | 0.77 | NOTUM (0.44) | NOTUMMEN1KMT2AP2RX4BCHE | |
| SCHEMBL13369000 | 0.75 | HDAC1 (0.43) | NOTUMPRKACAPRKACGPRKACBBCHE | |
| SCHEMBL20505774 | 0.74 | NOTUM (0.42) | NOTUMPRKACAPRKACGPRKACBP2RY1 | |
| SCHEMBL30681400 | 0.74 | KDM1A (0.46) | NOTUMPRKACAPRKACGPRKACBBCHE | |
| SCHEMBL13369003 | 0.73 | HDAC1 (0.42) | NOTUMPRKACAPRKACGPRKACBBCHE | |
| SCHEMBL7266754 | 0.72 | HTR4 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0511879-B1 | Pyrazine derivatives | OTSUKA PHARMA CO LTD (JP) | 1995-03-22 | — | — | EP | disclosed |