Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.76 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.76 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.76 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.76 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.76 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.76 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.76 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.76 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.76 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.76 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.76 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.63 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.63 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.63 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.63 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.63 |
| ▸ | MMP13 | P45452 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31235656 | 1.00 | HDAC1 (0.76) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL14096075 | 0.90 | HDAC3 (0.62) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL9220536 | 0.86 | HDAC1 (0.58) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL4518602 | 0.86 | HDAC1 (0.76) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL9219281 | 0.85 | HDAC1 (0.57) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL4522796 | 0.85 | HDAC1 (0.74) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL5089680 | 0.85 | HDAC1 (0.73) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL5318759 | 0.83 | LMNA (0.64) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL34468836 | 0.83 | KDM4E (0.71) | HPGDSMN1; SMN2ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL15657321 | 0.83 | TAS1R3 (0.55) | HDAC1HDAC3HDAC2HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512570-B1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-10-11 | — | — | EP | disclosed |
| CN-1067886-A | New urea derivatives, their preparation method and pharmaceutical composition thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1993-01-13 | — | — | CN | disclosed |
| EP-0512570-A1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-11 | — | — | EP | disclosed |