SCHEMBL9212840

SCHEMBL9212840

CCc1ncnc(NC(CC)c2ccc(Oc3c(F)c(F)c(C(F)(F)F)c(F)c3F)cc2)c1Cl

nearest known ligand 0.35

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.35
EGFR P00533 2/20 0.33
CRHR1 P34998 2/20 0.32
AKT1 P31749 6/20 0.31
RPS6KB1 P23443 2/20 0.31
PIK3CD O00329 2/20 0.30
PIK3CG P48736 2/20 0.30
PIK3CB P42338 1/20 0.30
PTGER4 P35408 1/20 0.30
AURKA O14965 1/20 0.30
PDPK1 O15530 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9212072 0.92 EGFR (0.36) EGFRCRHR1AKT1RPS6KB1PTGER4
SCHEMBL9208274 0.86 PIK3CD (0.34) EGFRCRHR1RPS6KB1PIK3CDPIK3CG
SCHEMBL9084666 0.84 PTGER4 (0.40) EGFRCRHR1RPS6KB1PTGER4AURKA
Hydrochloric Acid SCHEMBL9523871 0.83 PTGER4 (0.39) EGFRCRHR1RPS6KB1PTGER4AURKA
SCHEMBL9216328 0.81 AURKA (0.42) EGFRCRHR1AKT1RPS6KB1AURKA
SCHEMBL9215501 0.81 EGFR (0.36) EGFRCRHR1AKT1RPS6KB1AURKA
SCHEMBL9728933 0.81 IDH1 (0.37) EGFRCRHR1
SCHEMBL9729031 0.81 EGFR (0.36) EGFRCRHR1AKT1RPS6KB1PTGER4
SCHEMBL9523756 0.80 CRHR1 (0.39) EGFRCRHR1AKT1RPS6KB1PTGER4
SCHEMBL9524057 0.80 EGFR (0.36) EGFRCRHR1AKT1RPS6KB1PIK3CD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0370704-B1 Aralkylamine derivatives, preparation thereof and fungicides containing the same UBE INDUSTRIES (JP) 1995-02-01 EP disclosed
US-5141941-A ARALKYLAMINE DERIVATIVES, AND FUNGICIDES CONTAINING THE SAME UBE INDUSTRIES, LTD. (JP) 1992-08-25 US disclosed
EP-0370704-A2 Aralkylamine derivatives, preparation thereof and fungicides containing the same UBE INDUSTRIES, LTD. (JP) 1990-05-30 EP disclosed