Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.42 |
| ▸ | PANK3 | Q9H999 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.35 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9214586 | 0.88 | LMNA (0.46) | LMNAHTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9220790 | 0.83 | MEN1 (0.47) | LMNAHTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9270932 | 0.81 | LMNA (0.52) | LMNAHTTMEN1KMT2ASMN1; SMN2 | |
| Pirodavir SCHEMBL146440 | 0.79 | HRH3 (0.46) | LMNAHTTKMT2AMAPTGPR119 | |
| SCHEMBL9209752 | 0.78 | HRH3 (0.44) | LMNAHTTMAPTGPR119L3MBTL1 | |
| SCHEMBL9218863 | 0.78 | HRH3 (0.44) | LMNAHTTMAPTGPR119L3MBTL1 | |
| SCHEMBL10588330 | 0.78 | MEN1 (0.49) | LMNAHTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10588331 | 0.78 | MEN1 (0.49) | LMNAHTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7492587 | 0.77 | LMNA (0.45) | LMNAHTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9219673 | 0.77 | NPC1 (0.43) | LMNAHTTMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0320032-B1 | Pyridizinamine derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1995-01-18 | — | — | EP | disclosed |
| US-5231184-A | Viricide intermediate | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-07-27 | — | — | US | disclosed |
| US-5106973-A | Viricide intermediates | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-04-21 | — | — | US | disclosed |
| US-4992433-A | Viricides | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-02-12 | — | — | US | disclosed |