⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9219374 | 0.84 | ALOX5 (0.36) | — | |
| SCHEMBL9217627 | 0.84 | ALOX5 (0.36) | — | |
| SCHEMBL9219196 | 0.84 | ALOX5 (0.36) | — | |
| SCHEMBL9227921 | 0.81 | CCR2 (0.32) | — | |
| SCHEMBL9227917 | 0.81 | CCR2 (0.32) | — | |
| SCHEMBL9209049 | 0.80 | OPRM1 (0.39) | — | |
| SCHEMBL9226479 | 0.80 | OPRM1 (0.39) | — | |
| SCHEMBL9226485 | 0.80 | OPRM1 (0.39) | — | |
| SCHEMBL9197677 | 0.76 | ALOX5 (0.37) | — | |
| SCHEMBL9049332 | 0.76 | ALOX5 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0385662-B1 | Heterocycles with inhibitory activity of 5-lipoxygenase | ZENECA LTD (GB) | 1995-12-13 | — | — | EP | disclosed |
| US-5401751-A | Enzyme inhibitors for 5-lipoxygenase | ZENECA LIMITED (GB) | 1995-03-28 | — | — | US | disclosed |
| US-5236919-A | Inhibitorsof enzyme 5-lipoxygenase | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |
| US-5134148-A | Heterocycles for use as inhibitors of leukotrienes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-28 | — | — | US | disclosed |
| EP-0385662-A2 | Heterocycles with inhibitory activity of 5-lipoxygenase | ZENECA LIMITED (GB) | 1990-09-05 | — | — | EP | disclosed |